The paper addresses the issue of business clusters and their skills to improve the economic development of companies and regions. The main factors that influence the identification, promotion and support the development of business clusters are considerate. A set of statistical methods used to identify the economic concentration and specialised geographical areas, with significant concentration of economic activities are reviewed and applied for Romania. The results gained in this way are the first step in the process of identification of cluster type agglomeration, able to generated economic benefits for companies and their regions. The methods are integrated into a Geographic Information System, which allows the usage of spatial characteristics to represent and display the achieved results, on the map.