The economic development that preceded the economic crisis of 2008 has caused a lack of staff on the labor market, in particular of specialists in certain key areas, in all developed countries. The acute shortage of skilled staff at European level is also found among Romania, where companies play an important role in defining society at local and regional level. Romania has about 19 million people, of whom only 5 million are full-time employees, and the labor market estimates a shortage of more than 1 million employees in 2021, according to a study by audit and consulting firm PwC. In this respect, it was considered appropriate to analyze two development macroregions in Romania, which register smallest, respectively the and largest population in terms of national level. The general objective of the research is to identify the macroregion that has a greater potential for making private and even public investments. In this way, the method of multicriteria analysis at the level of applied methodology was used, so that current and future entrepreneurs can observe a clear delimitation of the two opposite areas of the country, regarding the existing potential on the labor market. Being positioned in opposite parts of the country, Macroregion Two and Macroregion Four each have certain specific economic characteristics, which can lead to a sustainable maroregional strategy for on the stability and prosperity of the labor market.