The reconfiguration of global supply chains, accelerated by the pandemic, geopolitical conflicts and economic pressures, is causing companies to seek for safer, faster and closer solutions to markets. In the context of the transition from global supply chains to regional models, Romania is consolidating its position as a strategic logistics hub in Central and Eastern Europe. Its advantageous geographical positioning, access to the Black Sea through the Port of Constanta, as well the membership in the European Union, provide Romania with a favorable framework for attracting investments in infrastructure and logistics. The objectives of the research propose to identify and highlight the country's competitive advantages, such as low operational costs, a skilled workforce and access to European funds, in the context of the reconfiguration of global logistics chains to regional models, but also persistent challenges, such as insufficiently developed road and rail infrastructure, administrative bureaucracy and labor migration. Amid both progress and persistent challenges, investments in supply chain digitalization are emerging as a cornerstone of future competitiveness. Digital transformation is vital for enhancing efficiency and ensuring transparency. Romania is making notable strides in this area, with investments in automated logistics centers, IoT technologies, and transport management platforms. However, the digital divide between large enterprises and SMEs continues to pose a significant challenge. Romania stands at a pivotal crossroads. Through strategic vision, sustainable investment, and a cohesive approach to logistics development, the country has the opportunity to evolve from a mere transit corridor into a central hub within European supply chains. The future of Romania’s logistics sector hinges on its ability to convert potential into tangible performance.