The article is intended to analyze the role of county chambers of commerce and industry from Romania from the perspective of the small and medium enterprises (SMEs) based in Romania. Consequently, we conducted a survey among the Romanian SMEs in order to identify the strengths and weaknesses they consider in relation with county chambers of commerce and industry from Romania. The article includes also a comparative analysis of the structure, legal status of chambers of commerce system around the world, highlighting the advantages and disadvantages of each law model. The article end with proposals made following the assessment regarding the position of SMEs in relation with the county chambers of commerce and industry from Romania.