Europe and the world have changed. The 21st century brings new challenges and new opportunities. The interaction of economies and peoples worldwide – whether by communication, trade, migration, shared security, concerns or cultural ex-change – is in constant evolution.European Union needs a unitary and coherent action in many fields (energy security, foreign policy, fight against terrorism and drugs, climate change, etc).The Treaty of Lisbon must fulfill these goals. In the last two years, much less attention has been given to the practical implementation of new institutional proposals included in the Treaty of Lisbon. Even a cursory examination indicates that the implementation of some of these proposals is likely to be uneasy, and in some cases could be a source of future problems or difficulties.Many voices said that there are only cosmetic differences between the former European Constitution and the Treaty of Lisbon.The European political context has changed after the recent elections for the European Parliament.The Treaty of Lisbon’s failure will have negative effects for the future of European continent.The aim of this paper is to highlight, and to clarify potential problems.